Author

Sicheng Pang

Boston University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:multiome· 1

Frequent Co-Authors

Mark W. GrinstaffiD· 2 shared Wilson W. WongiD· 2 shared Aidan T. RileyiD· 1 shared Alexander A. GreeniD· 1 shared Colin PorteriD· 1 shared Dana C. ShawiD· 1 shared Elijah Hammarlund· 1 shared Emily K. OsterweiliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Mark W. GrinstaffORCID

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2 papers

Recent·Most cited

Modified self-amplifying RNA mediates robust and prolonged gene expression in the mouse and ex vivo human brain

Jennifer Freire, Sicheng Pang, Joshua E. McGee, Maxwell J. Heinrich, Jiancheng Xie, Elijah Hammarlund, Dana C. Shaw, Yuxin Zhou, Yangyang Wang, Colin Porter, Lauren Dang, Erynne San Antonio, Ziqing Yu, K. Li, Scellig Stone, , Xue Han

This paper demonstrates that modified self-amplifying RNA (saRNA) enables long-lasting protein expression in mouse and human brain tissues.

bioRxiv · Oct 30, 2025 · PreprintNeuroscience

A Unified Framework for Model-Informed and Agentic RNA Design

Aidan T. Riley, McKayla Vlasity, Wyatt M. Becicka, Juanjuan Huang, Sicheng Pang, Wilson W. Wong, Mark W. Grinstaff, Alexander A. Green

This paper introduces a framework for model-informed mRNA design using integrated gradients and an agentic hypothesis engine, achieving improved in vivo expression.

bioRxiv · Jun 17, 2025 · PreprintSynthetic Biology