Interleukin 22 mediates interleukin 23-induced pathology in newborn mice by disrupting the function of pancreatic and intestinal cells
Glaucia C. Furtado, Lili Chen, Valentina Strohmeier, Zhengxiang He, Madhura Deshpande, Scott K. Durum, Thomas M. Moran, Thomas Kraus, Huabao Xiong, Jeremiah J. Faith, Sergio A. Lira
This study shows that IL-23-induced pathology in newborn mice is mediated by IL-22, which disrupts pancreatic and intestinal cell function, leading to malabsorption and early death.
bioRxiv · Jul 2, 2018 · PreprintImmunology