Author

Sean A. Higgins

Innovative Genomics Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein design· 2 Assay:protein sequence· 1

Frequent Co-Authors

David F. SavageiD· 2 shared Arik ShamsiD· 1 shared Benjamin L. Oakes· 1 shared Brett T. Staahl· 1 shared Christof FellmanniD· 1 shared Jennifer A. DoudnaiD· 1 shared Madeline L. ArnoldiD· 1 shared Maria LukarskaiD· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

David F. SavageORCID

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2 papers

Recent·Most cited

Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules

Arik Shams, Sean A. Higgins, Christof Fellmann, Thomas G. Laughlin, Benjamin L. Oakes, Rachel Lew, Shineui Kim, Maria Lukarska, Madeline L. Arnold, Brett T. Staahl, Jennifer A. Doudna, David F. Savage

The paper uses a genetic minimization technique to identify minimal DNA-binding modules in Cas9, showing that large domain deletions can retain function.

Nature Communications · Sep 27, 2021Peer-reviewedMolecular Biology

Rapid and Programmable Protein Mutagenesis Using Plasmid Recombineering

Sean A. Higgins, Sorel V. Yigma Ouonkap, David F. Savage

This paper demonstrates plasmid recombineering as a method for rapid and programmable protein mutagenesis, showing it can generate comprehensive libraries and identify improved variants.

ACS Synthetic Biology · Jul 14, 2017Peer-reviewedSynthetic Biology