Author

Sebastian Pena

Joslin Diabetes Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alejandro PenaiD· 1 shared Ayush D. MidhaiD· 1 shared Christopher Cahill· 1 shared Cristian AbarcaiD· 1 shared Cristina Aguayo‐MazzucatoiD· 1 shared Dylan S. BakeriD· 1 shared Francesko HelaiD· 1 shared Francisco G. CigarroaiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperDevelopmental Biology

Alejandro PenaORCID

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1 paper

Recent·Most cited

A human and mouse subpopulation of senescent β-cells induces pathologic dysfunction through targetable paracrine signaling

Kanako Iwasaki, Priscila Carapeto, Cristian Abarca, Francesko Hela, Stephanie Sanjines, Sebastian Pena, Sandra M. Le, Hui Pan, Christopher Cahill, Ayush D. Midha, Juliana Alcoforado Diniz, Dylan S. Baker, Sergii Domanskyi, Sara Espinoza, Alejandro Pena, , Cristina Aguayo‐Mazzucato

The paper identifies senescent β-cell subpopulations in humans and mice that induce pathologic dysfunction through paracrine signaling and shows JAK inhibitors can reverse this effect.

bioRxiv · May 7, 2025 · PreprintDevelopmental Biology