INPP5D/SHIP1 regulates inflammasome activation in human microglia
Vicky Chou, Seeley B. Fancher, Richard V. Pearse, Hyo Lee, Matti Lam, Nicholas T. Seyfried, David Alan Bennett, Philip L. De Jager, Vilas Menon, Tracy L. Young‐Pearse
This study shows that INPP5D/SHIP1 regulates inflammasome activation in human microglia, with reduced INPP5D leading to increased IL-1β and IL-18 secretion.
bioRxiv · Feb 25, 2023 · PreprintNeuroscience