Author

Vicky Chou

Brigham and Women's HospitalORCID 0000-0001-8642-491XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:proteomics· 1

Frequent Co-Authors

Tracy L. Young‐PearseiD· 3 shared David Alan BennettiD· 2 shared Hyo LeeiD· 2 shared Nicholas T. SeyfriediD· 2 shared Philip L. De JageriD· 2 shared Richard V. PearseiD· 2 shared Vilas MenoniD· 2 shared Aaron HeldiD· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersNeuroscience

Tracy L. Young‐PearseORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

NeuroscienceNeuronPeer-reviewedMar 13, 2023

Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration

Dylan V. Neel, Himanish Basu, Georgia Gunner…·Isaac M. Chiu

This study identifies GSDME as a mediator of mitochondrial damage and axon loss in neurodegenerative diseases, showing its role in ALS and FTD models.

139 citationstop 1%

mousehuman

𝕏 PostBluesky

NeurosciencebioRxivPreprintFeb 25, 2023

INPP5D/SHIP1 regulates inflammasome activation in human microglia

Vicky Chou, Seeley B. Fancher, Richard V. Pearse…·Tracy L. Young‐Pearse

This study shows that INPP5D/SHIP1 regulates inflammasome activation in human microglia, with reduced INPP5D leading to increased IL-1β and IL-18 secretion.

8 citations

humanbulk RNA-seq

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NeurosciencebioRxivPreprintFeb 25, 2023

Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer's disease risk gene SORL1

Hyo Lee, Aimee J. Aylward, Richard V. Pearse…·Tracy L. Young‐Pearse

This study shows that SORL1 loss reduces APOE levels specifically in neurons and astrocytes, linking SORL1 and APOE to Alzheimer's disease risk through distinct pathways.

4 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintMay 2, 2020

Identification of synaptic PPT1 substrates highlight roles of depalmitoylation in disulfide bond formation and synaptic function

Erica L. Gorenberg, Sofia Massaro Tieze, Betül Yücel…·Sreeganga S. Chandra

The paper identifies PPT1 substrates in mouse brains, showing depalmitoylation's role in disulfide bond formation and synaptic function, with over 100 novel substrates found.

2 citations

mouseproteomics

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