Author

Matti Lam

Rush University Medical CenterORCID 0000-0002-1853-4209Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1

Frequent Co-Authors

David Alan BennettiD· 3 shared Philip L. De JageriD· 3 shared Vilas MenoniD· 3 shared Dylan I. LeeiD· 2 shared Anthony KhairallahiD· 1 shared Archana YadaviD· 1 shared Courteney MattisoniD· 1 shared David X. MárqueziD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersNeuroscience

David Alan BennettORCID

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Author profile →

3 papers

Recent·Most cited

Cell type-specific associations with Alzheimer's Disease conserved across racial and ethnic groups

Tain Luquez, Jonathan Algoo, Rebecca Chiu, Jason A. Mares, Archana Yadav, Matti Lam, Pallavi Gaur, Xiaoying Lai, Dylan I. Lee, Fahad Paryani, Rafe Batchelor, Irla Belli, Jordan Henry, Courteney Mattison, Luke Starr, , Vilas Menon

The paper identifies cell-type-specific and continuous gene programs associated with Alzheimer's Disease across multiple racial and ethnic groups using single-nucleus RNA-seq and ATAC-seq.

bioRxiv · Apr 14, 2025 · PreprintNeuroscience

Human disease-specific cell signatures in non-lesional tissue in Multiple Sclerosis detected by single-cell and spatial transcriptomics

Matti Lam, Dylan I. Lee, Ivy M Kosater, Anthony Khairallah, Mariko F. Taga, Ya Zhang, Masashi Fujita, Sukriti Nag, David Alan Bennett, Philip L. De Jager, Vilas Menon

The paper identifies disease-specific cell signatures in non-lesional brain tissue of MS patients using single-cell and spatial transcriptomics.

bioRxiv · Dec 20, 2023 · PreprintNeuroscience

INPP5D/SHIP1 regulates inflammasome activation in human microglia

Vicky Chou, Seeley B. Fancher, Richard V. Pearse, Hyo Lee, Matti Lam, Nicholas T. Seyfried, David Alan Bennett, Philip L. De Jager, Vilas Menon, Tracy L. Young‐Pearse

This study shows that INPP5D/SHIP1 regulates inflammasome activation in human microglia, with reduced INPP5D leading to increased IL-1β and IL-18 secretion.

bioRxiv · Feb 25, 2023 · PreprintNeuroscience