Biased M1 positive allosteric modulators reveal novel role of phospholipase D in M1-dependent rodent cortical plasticity
Sean P. Moran, Zixiu Xiang, Catherine A. Doyle, James Maksymetz, Xiaohui Lv, Sehr Faltin, Nicole M. Fisher, Aaron M. Bender, Colleen Marie Niswender, Jerri M. Rook, Craig W. Lindsley, Peter Jeffrey Conn
The paper shows that phospholipase D is essential for M1 PAM-induced long-term depression in rodent prefrontal cortex, and biased M1 PAMs that do not activate PLD have distinct effects on cortical plasticity.
Science Signaling · Dec 3, 2019Peer-reviewedNeuroscience