CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations
Ida Höijer, Anastasia Emmanouilidou, Rebecka Östlund, Robin van Schendel, Selma Bozorgpana, Marcel Tijsterman, Lars Feuk, Ulf B Gyllensten, Marcel den Hoed, Adam Ameur
This study shows CRISPR-Cas9 induces structural variants and off-target mutations in zebrafish that persist through generations.
Nature Communications · Feb 2, 2022Peer-reviewedGenomics