Ulf B Gyllensten

Genomic and Dietary Insights from Non-Invasive Sampling of Western Capercaillie in Tyresta National Park (Sweden)

This study uses genomic and dietary data from non-invasive samples to assess the genetic health and diet of a Western Capercaillie population in Sweden, finding low inbreeding but risks from small size and isolation.

Genetic mechanisms of 184 neuro-related proteins in human plasma

The paper identifies genetic regulators of 184 neuro-related proteins in human plasma and links them to disease traits and drug targets.

Mapping pQTLs of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and novel therapeutic targets

The paper identifies pQTLs for 91 plasma proteins, finds novel associations, and uses MR to uncover causal roles in immune-mediated diseases, suggesting new therapeutic targets.

Genome-wide association study reveals loci with sex-specific effects on plasma bile acids

The paper identifies sex-specific genetic loci associated with plasma bile acid levels using GWAS in a population-based cohort.

CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations

This study shows CRISPR-Cas9 induces structural variants and off-target mutations in zebrafish that persist through generations.

Mapping genetic determinants of 184 circulating proteins in 26,494 individuals to connect proteins and disease.

This study identifies 592 genetic loci associated with 184 plasma proteins in 26,494 individuals and finds causal relationships between protein levels and disease.

Amplification-free long read sequencing reveals unforeseen CRISPR-Cas9 off-target activity

The paper introduces amplification-free long-read sequencing protocols to detect CRISPR-Cas9 off-target binding sites, identifying many previously undetected sites that are not predicted by existing software.

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

The paper identifies pQTLs for cardiovascular proteins and uses them to evaluate drug targets and suggest new candidates for precision medicine.

SweHLA: the high confidence HLA typing bio-resource drawn from 1 000 Swedish genomes

The paper develops SweHLA, a high-confidence HLA typing resource from 1,000 Swedish genomes, showing high concordance across software and highlighting discordant alleles potentially linked to disease.

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

The paper identifies 279 new genetic signals for lung function across multiple ancestries, showing associations with COPD and pleiotropic effects.

The Medical Genome Reference Bank: Whole genomes and phenotype of 2,570 healthy elderly

The paper introduces the Medical Genome Reference Bank, a resource of whole genome sequences and phenotypes from 2,570 healthy elderly Australians, showing fewer disease-associated variants and age-related somatic changes linked to grip strength.

De novo assembly of two Swedish genomes reveals missing segments from the human GRCh38 reference and improves variant calling of population-scale sequencing data

The paper performs de novo assembly of two Swedish genomes, identifies novel sequences absent from GRCh38, and shows improved variant calling with these sequences.

Amplification-free, CRISPR-Cas9 Targeted Enrichment and SMRT Sequencing of Repeat-Expansion Disease Causative Genomic Regions

Combining amplification-free CRISPR-Cas9 targeted enrichment with Single Molecule, Real-Time (SMRT) long-read sequencing captures and sequences human repeat-expansion disease loci across HTT, FMR1, C9orf72, and ATXN10 without PCR bias.

SweGen: A whole-genome map of genetic variability in a cross-section of the Swedish population

SweGen provides a high-quality whole-genome map of genetic variation in the Swedish population, useful for clinical genetics and association studies.