Marcel den Hoed

The paper identifies genetic variants near SLC2A2 that influence glycemic response to glimepiride in type 2 diabetes patients.

This study uses long-read sequencing to analyze CRISPR-Cas9 editing outcomes and mosaicism in zebrafish, revealing genetic mosaicism in founder fish and its inheritance to offspring.

This study identifies novel causal genes for NAFLD using a combination of GWAS, genetic colocalization, and CRISPRi functional screens.

The paper introduces Kita as a target for CRISPR/Cas9 screens in zebrafish larvae to improve the reliability and efficiency of genetic screens for complex traits.

This study shows CRISPR-Cas9 induces structural variants and off-target mutations in zebrafish that persist through generations.

The paper introduces amplification-free long-read sequencing protocols to detect CRISPR-Cas9 off-target binding sites, identifying many previously undetected sites that are not predicted by existing software.

The paper uses a CRISPR/Cas9-based approach in zebrafish to identify genes affecting heart rate variability and confirms the role of known genes while highlighting a novel gene.

This study identifies 370 genetic loci associated with age at first sex and birth, linking them to externalising behaviour and reproductive biology.

The paper develops a zebrafish pipeline to study dyslipidemia and atherosclerosis, identifying potential causal genes and showing drug effects.

This paper introduces SAPPHO methods to detect pleiotropy in GWAS by modeling shared patterns of genetic associations, finding 16 additional and 124 novel loci in meta-analysis.

This study identifies 47 novel genetic loci associated with PR interval through genome-wide association meta-analysis across multiple populations.