ATP Citrate Lyase Supports Cardiac Function and NAD+/NADH Balance And Is Depressed in Human Heart Failure
Mariam Meddeb, Navid Koleini, Seungho Jun, Mohammad Keykhaei, Farnaz Farshidfar, Liang Zhao, Seoyoung Kwon, Brian Lin, Gizem Keceli, Nazareno Paolocci, Virginia Shalkey Hahn, Kavita Sharma, Erika L. Pearce, David A. Kass
This study investigates the role of ATP citrate lyase (ACLY) in cardiac function and NAD+/NADH balance, finding it is reduced in heart failure and its inhibition impairs cardiac function and metabolism.
bioRxiv · Jun 9, 2024 · PreprintMolecular Biology