Author

Seoyun Heo

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Angelina M. CicerchiaiD· 1 shared Ashwin V. KammulaiD· 1 shared Claire A. Palin· 1 shared Cun Lan ChuongiD· 1 shared Erin N. Kistler· 1 shared Genevieve Marie BolandiD· 1 shared Jessica A. Talamas· 1 shared John G. DoenchiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Angelina M. CicerchiaORCID

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1 paper

Recent·Most cited

CREB5 promotes immunotherapy resistance via tumor-intrinsic collagenmatrix deposition

Payal Tiwari, Kayla J. Colvin, Sarah Y. Kim, Ashwin V. Kammula, Jordan M. Chinai, Nuno Alfaiate, Or‐Yam Revach, Erin N. Kistler, Seoyun Heo, Seth Anderson, Sydney M. Moyer, Zhengyang Sun, Angelina M. Cicerchia, Claire A. Palin, Maulik Vyas, , Robert T. Manguso

The paper identifies CREB5 as a driver of immunotherapy resistance in melanoma by promoting collagen matrix deposition, which activates LAIR1 signaling on immune cells.

bioRxiv · Apr 22, 2025 · PreprintCancer Biology