Author

Jordan M. Chinai

Broad InstituteORCID 0000-0002-3236-498XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Kathleen B. YatesiD· 2 shared Robert T. MangusoiD· 2 shared Alexánder RojasiD· 1 shared Angelina M. CicerchiaiD· 1 shared Ashwin V. KammulaiD· 1 shared Audrey J. MuscatoiD· 1 shared Chun‐Cheih ChaoiD· 1 shared Claire A. Palin· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBioengineering

Kathleen B. YatesORCID

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2 papers

Recent·Most cited

In vivo generation of chimeric antigen receptor T cells using optimally retargeted and functionalized lentiviral vectors with reduced immune clearance

Kepler S. Mears, Kyrellos E. Ibrahim, Peter M. Allen, Jordan M. Chinai, Omar I. Avila, Audrey J. Muscato, Sarah Kate Lane-Reticker, Alexánder Rojas, Nelson H. Knudsen, Chun‐Cheih Chao, Kathleen B. Yates, Robert T. Manguso

This study develops lentiviral vectors with improved specificity and reduced immune clearance for in vivo CAR T cell generation, showing efficacy in a preclinical model.

bioRxiv · Apr 23, 2025 · PreprintBioengineering

CREB5 promotes immunotherapy resistance via tumor-intrinsic collagenmatrix deposition

Payal Tiwari, Kayla J. Colvin, Sarah Y. Kim, Ashwin V. Kammula, Jordan M. Chinai, Nuno Alfaiate, Or‐Yam Revach, Erin N. Kistler, Seoyun Heo, Seth Anderson, Sydney M. Moyer, Zhengyang Sun, Angelina M. Cicerchia, Claire A. Palin, Maulik Vyas, , Robert T. Manguso

The paper identifies CREB5 as a driver of immunotherapy resistance in melanoma by promoting collagen matrix deposition, which activates LAIR1 signaling on immune cells.

bioRxiv · Apr 22, 2025 · PreprintCancer Biology