Author

Claire A. Palin

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Genevieve Marie BolandiD· 2 shared Or‐Yam RevachiD· 2 shared Russell William JenkinsiD· 2 shared A G MurrayiD· 1 shared Aleigha R. LawlessiD· 1 shared Alfredo Quijano‐RubioiD· 1 shared Angelina M. CicerchiaiD· 1 shared Asheema Khanna· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

Genevieve Marie BolandORCID

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2 papers

Recent·Most cited

Potent antitumor activity of a designed interleukin-21 mimic

Jung-Ho Chun, Birkley S. Lim, Suyasha Roy, Michael J. Walsh, Gita C. Abhiraman, Kevin Zhangxu, Tavus Atajanova, Or‐Yam Revach, Elisa C. Clark, Peng Li, Claire A. Palin, Asheema Khanna, Samantha J Tower, Rakeeb Kureshi, Megan T. Hoffman, , David A. Baker

This paper describes a designed IL-21 mimic, 21h10, which shows potent antitumor activity in multiple models and reduces toxicity through TNF blockade.

Science Immunology · Sep 26, 2025Peer-reviewedBiochemistry

CREB5 promotes immunotherapy resistance via tumor-intrinsic collagenmatrix deposition

Payal Tiwari, Kayla J. Colvin, Sarah Y. Kim, Ashwin V. Kammula, Jordan M. Chinai, Nuno Alfaiate, Or‐Yam Revach, Erin N. Kistler, Seoyun Heo, Seth Anderson, Sydney M. Moyer, Zhengyang Sun, Angelina M. Cicerchia, Claire A. Palin, Maulik Vyas, , Robert T. Manguso

The paper identifies CREB5 as a driver of immunotherapy resistance in melanoma by promoting collagen matrix deposition, which activates LAIR1 signaling on immune cells.

bioRxiv · Apr 22, 2025 · PreprintCancer Biology