Author

Serina B Young

Columbia University Irving Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Charles L. SawyersiD· 1 shared Emmet Huang-HobbsiD· 1 shared Justin R. LaClairiD· 1 shared Kyrie PappasiD· 1 shared Marco Vincenzo RussoiD· 1 shared Maria JasiniD· 1 shared Matteo FerrariiD· 1 shared Nikolaus D. SchultziD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Charles L. SawyersORCID

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1 paper

Recent·Most cited

BRCA2 reversion mutation-independent resistance to PARP inhibition in prostate cancer through loss of function perturbations in the DNA pre-replication complex

Kyrie Pappas, Matteo Ferrari, Perianne Smith, Subhiksha Nandakumar, Zahra Khan, Serina B Young, Justin R. LaClair, Marco Vincenzo Russo, Emmet Huang-Hobbs, Nikolaus D. Schultz, Wassim M. Abida, Wouter R. Karthaus, Maria Jasin, Charles L. Sawyers

This study identifies loss of function mutations in the DNA pre-replication complex as a mechanism for PARP inhibitor resistance in BRCA-mutant prostate cancer, independent of reversion mutations.

bioRxiv · Apr 20, 2025 · PreprintCancer Biology