Author

Zahra Khan

Memorial Sloan Kettering Cancer CenterPrimary ORCID profile (0000-0001-5295-8286 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Zahra KhaniD1 paper · Gachon University

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Charles L. SawyersiD· 2 shared Nikolaus D. SchultziD· 2 shared Subhiksha NandakumariD· 2 shared Alexandre Gaspar‐MaiaiD· 1 shared Cláes DahlgreniD· 1 shared Emmet Huang-HobbsiD· 1 shared Fariha KhaniD· 1 shared Huamei Fu ForsmaniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

Charles L. SawyersORCID

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3 papers

Recent·Most cited

MYC pathway reprogramming through a TIP60 coactivator switch in neuroendocrine lineage transition in prostate cancer

Zhen Sun, Jimmy Zhao, Zahra Khan, Wazim Mohammed Ismail, Teng Han, Subhiksha Nandakumar, Serina Young, Matthew Lange, Pan Cheng, Richard P. Koche, Nikolaus Schultz, Alexandre Gaspar‐Maia, Charles L. Sawyers

The paper identifies a TIP60 coactivator switch in neuroendocrine prostate cancer, revealing a therapeutic target for MYC-driven diseases.

bioRxiv · May 8, 2026 · PreprintCancer Biology

The free fatty acid 2 receptor regulates the activation potency of C5a and the sensitivity to the antagonist avacopan

Zahra Khan, Neil Levin, Cláes Dahlgren, Martina Sundqvist, Fariha Khan, Huamei Fu Forsman, Lena I Björkman

This study shows that the free fatty acid 2 receptor modulates C5a receptor signaling, enhancing NADPH oxidase activation and reducing the effect of the antagonist avacopan.

bioRxiv · Oct 28, 2025 · PreprintCell Biology

BRCA2 reversion mutation-independent resistance to PARP inhibition in prostate cancer through loss of function perturbations in the DNA pre-replication complex

Kyrie Pappas, Matteo Ferrari, Perianne Smith, Subhiksha Nandakumar, Zahra Khan, Serina B Young, Justin R. LaClair, Marco Vincenzo Russo, Emmet Huang-Hobbs, Nikolaus D. Schultz, Wassim M. Abida, Wouter R. Karthaus, Maria Jasin, Charles L. Sawyers

This study identifies loss of function mutations in the DNA pre-replication complex as a mechanism for PARP inhibitor resistance in BRCA-mutant prostate cancer, independent of reversion mutations.

bioRxiv · Apr 20, 2025 · PreprintCancer Biology