Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression
Caroline Jane Ross, Yael Sarusi, Yoav Lubelsky, Rotem Ben‐Tov Perry, Anat Mavashov, Shaked Turk, Moran Rubinstein, Igor Ulitsky
The paper shows that ASOs targeting CHASERR induce fusion transcripts that increase CHD2 expression, alleviating haploinsufficiency in mice.
bioRxiv · May 28, 2025 · PreprintMolecular Biology