Author

Marina Brusel

Tel Aviv University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Assay:electronic health records· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Moran RubinsteiniD· 5 shared Anat MavashoviD· 3 shared Karen Anderson· 2 shared Shir QuinniD· 2 shared Yael AlmogiD· 2 shared Ana RicobarazaiD· 1 shared Bertrand BeucheriD· 1 shared Elena Cardenal‐MuñoziD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersNeuroscience

Moran RubinsteinORCID

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5 papers

Recent·Most cited

Alterations in background ECoG activity and behavioral deficits in a mouse model of CHD2-related developmental delay

Anat Mavashov, Shaked Turk, Yael Sarusi, Marina Brusel, Rotem Ben‐Tov Perry, Shir Quinn, Yael Almog, Karni Vilian, Igor Ulitsky, Moran Rubinstein

This paper characterizes behavioral and epileptic phenotypes in a CHD2 mutant mouse model, identifying genetic modifiers and altered ECoG activity associated with developmental delay.

bioRxiv · Mar 18, 2025 · PreprintNeuroscience

Heat-induced seizures, premature mortality, and hyperactivity in a novel Scn1a nonsense model for Dravet syndrome

Anat Mavashov, Marina Brusel, Jiaxing Liu, Victoria Woytowicz, Haneui Bae, Ying-Hsin Chen, Vardhan S. Dani, Elena Cardenal‐Muñoz, Vittoria Spinosa, José Ángel Aibar, Moran Rubinstein

This paper introduces a novel Dravet syndrome mouse model with a Scn1a R613X nonsense mutation, showing seizures, premature death, and hyperactivity.

Frontiers in Cellular Neuroscience · May 3, 2023Peer-reviewedNeuroscience

Acute effect of antiseizure drugs on background oscillations in Scn1aA1783V Dravet syndrome mouse model

Shir Quinn, Marina Brusel, Mor Ovadia, Moran Rubinstein

This study examines the acute effects of antiseizure drugs on background neuronal oscillations in a Dravet syndrome mouse model, finding that some drugs reduce interictal spikes and alter frequency bands while others do not.

Frontiers in Pharmacology · Mar 20, 2023Peer-reviewedNeuroscience

Exogenous Nav1.1 activity in excitatory and inhibitory neurons reverts Dravet syndrome comorbidities when delivered post-symptom onset in mice with Dravet

Saja Fadila, Bertrand Beucher, Iria G. Dopeso‐Reyes, Anat Mavashov, Marina Brusel, Karen Anderson, Ethan M. Goldberg, Ana Ricobaraza, Rubén Hernández-Alcoceba, Eric J. Kremer, Moran Rubinstein

This study shows that delivering a modified SCN1A gene via viral vectors to DS mice improves survival, reduces seizures, and corrects brain activity after symptom onset.

bioRxiv · Jun 10, 2022 · PreprintNeuroscience

Early hippocampal hyperexcitability followed by disinhibition in a mouse model of Dravet syndrome

Yael Almog, Marina Brusel, Karen Anderson, Moran Rubinstein

The paper analyzes the activity of hippocampal neurons in a mouse model of Dravet syndrome across different disease stages, finding temporary excitability increases in pyramidal neurons and persistent inhibition deficits in interneurons.

bioRxiv · Oct 3, 2019 · PreprintNeuroscience