Downregulation of NR4A3 during inactivity alters glucose metabolism and impairs translation in human skeletal muscle
Jonathon A.B. Smith, Brendan M. Gabriel, Ahmed M. Abdelmoez, Mladen Savikj, Shane C. Wright, Stefania Koutsilieri, Romain Barrès, Volker M. Lauschke, Anna Krook, Juleen R. Zierath, Nicolas J. Pillon
This study shows that reduced NR4A3 levels in skeletal muscle due to inactivity impair glucose metabolism, translation, and myotube size by affecting mTORC1 and ribosomal pathways.
bioRxiv · Mar 11, 2024 · PreprintCell Biology