Landscape of reversion alterations in homologous recombination genes reveals evolutionary constraints
Brennan James Decker, Saumya Dushyant Sisoudiya, James Thornton, Chenming Cui, Taku Harada, Shahlo O. Solieva, Russell William Madison, Arindam Datta, Tao Shi, Fabio Guintini, Zoe Fleischmann, Mark Hartman, Shannon Terrell Bailey, Jeffrey A. Leibowitz, Ethan S. Sokol, , Katherine L. Nathanson
The paper identifies reversion mutations in homologous recombination genes across cancers, showing they restore DNA repair and confer PARP inhibitor resistance through specific structural alterations.
bioRxiv · May 27, 2026 · PreprintCancer Biology