Shao‐Pei Chou

This study identifies Playrr, a lncRNA that regulates Pitx2 dosage and protects against cardiac arrhythmias by modulating cardiac gene expression and atrial substrate.

This study uses genetic variation in mice to show how DNA sequence affects RNA Polymerase II positioning and transcription dynamics across the genome.

The paper introduces a method to uncover transcriptionally active regions in scRNA-seq data beyond standard gene annotations, improving transcriptome coverage in understudied organisms.

The paper uses machine learning to show that transcription predicts histone marks and chromatin states, and that transcription is required for maintaining active and repressive histone modifications.

AlleleHMM identifies allele-specific differences in genomic marks using a hidden Markov model, outperforming existing methods in simulated and real data.