Carrie J. Finno

This study assesses the reproducibility of pathogenicity classification using the animal variant classification guidelines across three species, finding 65% reproducibility for pathogenicity and 83% clinically relevant agreement.

The paper identifies SEL1L's role in platelet function across species, showing it is necessary for platelet adhesion to injured sites.

The paper introduces a comprehensive equine allele-specific expression resource using integrated RNA sequencing and histone modification data from four Thoroughbreds across nine tissues.

The paper develops universal epigenetic clocks that accurately estimate age across mammalian tissues using DNA methylation data from 185 species.

This paper presents a comprehensive functional annotation of the horse genome, addressing limitations in current RNA-seq and comparative genomics approaches by integrating data from nine major tissues.

The paper improves the equine transcriptome annotation using long-read RNA sequencing, achieving 45% better completeness and enhanced identification of alternative splicing and noncoding genes.

This study identifies cisplatin's effect on specific subpopulations of TH+ DRGNs and shows K+ channel involvement in neurotoxicity.

This paper develops epigenetic clocks for horses using DNA methylation data from multiple tissues, showing age-related CpGs are near developmental genes and that castration does not significantly affect aging rate.

The paper develops epigenetic clocks and pacemaker models to predict age in plains zebras and other equids using DNA methylation data from blood samples.

The paper uses machine learning to show that transcription predicts histone marks and chromatin states, and that transcription is required for maintaining active and repressive histone modifications.

The paper presents an updated horse reference genome, EquCab3, which improves contiguity and composition compared to the previous version, EquCab2.

The paper develops two new SNP arrays for horses, MNEc2M and MNEc670k, and demonstrates their imputation capabilities.