Adriana K. Alexander

The paper identifies a transcriptional regulatory network in murine gonadal supporting cells that underlies sex differentiation, revealing how chromatin changes and gene expression drive Sertoli and granulosa cell fates.

This study shows that JQ1 disrupts meiotic prophase I in male mice, leading to reversible infertility, suggesting a potential non-hormonal contraceptive strategy.

This study uses single-nucleus multiomics to uncover gene regulatory networks and chromatin dynamics in murine PGCs during sex determination.

The paper investigates how A-MYB and BRDT regulate RNA polymerase II pause release during meiotic prophase I, linking transcriptional bursts to chromatin changes and recombination.

This study uses genetic variation in mice to show how DNA sequence affects RNA Polymerase II positioning and transcription dynamics across the genome.