Emergence of mutHV76G among longitudinal carbapenem resistant Klebsiella pneumoniae causing long-term colonization and recurrent infection disrupts DNA mismatch repair and results in a hypermutator phenotype
Shaoji Cheng, Cornelius Joseph Clancy, Giuseppe Fleres, Hassan Badrane, Matthew J. Culyba, Anthony Newbrough, Liang Chen, M. Hong Nguyen
This study identifies mutHV76G in K. pneumoniae causing hypermutation, antibiotic resistance, and plasmid acquisition without fitness cost.
bioRxiv · Nov 17, 2025 · PreprintMicrobiology