Matthew J. Culyba

This study compares high-depth whole genome sequencing of pooled (p-seq) and individual colonies (c5-seq) from blood culture plates to understand evolutionary dynamics in MRSA bacteremia, finding that c5-seq is more practical for tracking within-host evolution.

This study identifies mutHV76G in K. pneumoniae causing hypermutation, antibiotic resistance, and plasmid acquisition without fitness cost.