Liang Chen

This study identifies key genetic factors influencing cefiderocol resistance in ST258 Klebsiella pneumoniae using transposon mutagenesis.

This study removes virulence plasmids from two CR-hvKp strains, showing reduced virulence and fitness but strain-specific transcriptional changes and differential regulatory roles of rmp operons.

This paper develops and validates a targeted mass spectrometry assay for quantifying bacteriophages, demonstrating high accuracy and precision for LUZ19.

This study identifies a novel hypervirulent Klebsiella pneumoniae ST111 strain with a unique virulence plasmid causing pyogenic liver abscess, highlighting non-canonical lineages as potential sources of emerging virulence.

This study identifies mutHV76G in K. pneumoniae causing hypermutation, antibiotic resistance, and plasmid acquisition without fitness cost.

pGGTOX enables efficient, marker-free genome editing across Enterobacteriaceae using homologous recombination, with applications in gene deletion, plasmid modification, and CRISPR delivery.

This study validates cwlM and pbpB as essential genes for Mycobacterium abscessus viability and imipenem resistance using CRISPRi in vitro and in vivo.

The paper analyzes whole-genome sequencing data of Mycobacterium tuberculosis isolates to study lineage evolution and antigenic diversity in China and Zhejiang Province.

This study analyzes gut microbiota differences between healthy adults and chronic traumatic complete SCI patients, finding dysbiosis linked to serum biomarkers and neurogenic bowel dysfunction.