Author

Giuseppe Fleres

University of PittsburghORCID 0000-0002-2332-8960Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:whole-genome sequencing· 3 Research Focus:drug response / drug discovery· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Anthony NewbroughiD· 2 shared Hassan BadraneiD· 2 shared M. Hong NguyeniD· 2 shared Shaoji Cheng· 2 shared Akila MansouriD· 1 shared Binghua Hao· 1 shared Christopher L. DupontiD· 1 shared Cornelius Joseph ClancyiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

Anthony NewbroughORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Within-Patient Evolution of Pseudomonas aeruginosa Populations During Antimicrobial Treatment

Giuseppe Fleres, Ellen G Kline, Kevin M Squires, Tyler Tate, Hannah M. Creager, Ryan K. Shields, Daria Van Tyne

This study tracks genomic changes in Pseudomonas aeruginosa during antimicrobial treatment using single-isolate and metagenomic sequencing, revealing resistance mutations and population diversity.

mSphere · Mar 16, 2026Peer-reviewedEvolutionary Biology

Emergence of mutHV76G among longitudinal carbapenem resistant Klebsiella pneumoniae causing long-term colonization and recurrent infection disrupts DNA mismatch repair and results in a hypermutator phenotype

Shaoji Cheng, Cornelius Joseph Clancy, Giuseppe Fleres, Hassan Badrane, Matthew J. Culyba, Anthony Newbrough, Liang Chen, M. Hong Nguyen

This study identifies mutHV76G in K. pneumoniae causing hypermutation, antibiotic resistance, and plasmid acquisition without fitness cost.

bioRxiv · Nov 17, 2025 · PreprintMicrobiology

Blood cultures contain populations of genetically diverse Candida albicans strains that may differ in echinocandin tolerance and virulence

Giuseppe Fleres, Shaoji Cheng, Hassan Badrane, Christopher L. Dupont, Josh L. Espinoza, Darren Abbey, Eileen Driscoll, Anthony Newbrough, Binghua Hao, Akila Mansour, M. Hong Nguyen, Cornelius Joseph Clancy

The paper identifies genetically diverse Candida albicans strains in blood cultures that differ in echinocandin tolerance and virulence, with implications for antifungal treatment.

bioRxiv · Oct 16, 2024 · PreprintMicrobiology