Bacterial surface display enables lysis-independent joint host-pathogen single-cell profiling
Cal Gunnarsson, Jeff C. Hsiao, Jacob B. Hochfelder, Sydney L. Solomon, Bianca A. Lepe, Sharon Zhu, Kelly Xu, Hattie Chung, Bryan D. Bryson
This paper introduces a lysis-independent method for joint host-pathogen single-cell profiling using bacterial surface display, enabling analysis of both host and pathogen features in infected cells.
bioRxiv · Jul 22, 2026 · PreprintBioengineering