Author

Bianca A. Lepe

Ragon Institute of MGH, MIT and Harvard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1 Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Bryan D. BrysoniD· 3 shared Sydney L. SolomoniD· 2 shared Benjamin L. AllsupiD· 1 shared Cal Gunnarsson· 1 shared Christine R. Zheng· 1 shared Christopher M. SassettiiD· 1 shared Clifford V. HardingiD· 1 shared Daniel P. GailiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

Bryan D. BrysonORCID

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Author profile →

4 papers

Recent·Most cited

Human memory CD4+ T cells recognize non-infected macrophage bystanders exposed to Mycobacterium tuberculosis-infected cells

Vinicius G. Suzart, Robert Schauner, Scott M. Reba, Daniel P. Gail, Gwendolyn M. Swarbrick, David Michael Lewinsohn, Deborah A. Lewinsohn, Bianca A. Lepe, Bryan D. Bryson, Samuel M. Behar, Christopher M. Sassetti, Michael L. Freeman, W Henry Boom, Clifford V. Harding, Stephen M. Carpenter

The paper shows human memory CD4+ T cells recognize both Mtb-infected and bystander macrophages, with some TCRs specifically recognizing infected cells.

bioRxiv · Sep 24, 2026 · PreprintImmunology

Bacterial surface display enables lysis-independent joint host-pathogen single-cell profiling

Cal Gunnarsson, Jeff C. Hsiao, Jacob B. Hochfelder, Sydney L. Solomon, Bianca A. Lepe, Sharon Zhu, Kelly Xu, Hattie Chung, Bryan D. Bryson

This paper introduces a lysis-independent method for joint host-pathogen single-cell profiling using bacterial surface display, enabling analysis of both host and pathogen features in infected cells.

bioRxiv · Jul 22, 2026 · PreprintBioengineering

Protease shaving of Mycobacterium tuberculosis facilitates vaccine antigen discovery anddelivery of novel cargoes to the Mtb surface

Bianca A. Lepe, Christine R. Zheng, Owen K. Leddy, Benjamin L. Allsup, Sydney L. Solomon, Bryan D. Bryson

This study identifies Mtb outer membrane proteins using protease shaving and mass spectrometry, revealing novel vaccine targets and methods to deliver cargoes to the Mtb surface.

Microbiology Spectrum · Dec 17, 2024Peer-reviewedMicrobiology

Sequence-to-function deep learning frameworks for synthetic biology

Jacqueline A. Valeri, Katherine M. Collins, Bianca A. Lepe, Timothy K. Lu, Diogo M. Camacho

The paper introduces STORM, a deep learning model to optimize toehold switches by analyzing sequence-to-function relationships in a dataset of 91,534 toehold switches.

bioRxiv · Dec 10, 2019 · PreprintSynthetic Biology