Author

Jacob B. Hochfelder

Ragon Institute of MGH, MIT and Harvard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Bryan D. BrysoniD· 2 shared Cal Gunnarsson· 2 shared Ajay S. ThatteiD· 1 shared Avinash K. Gadok· 1 shared Bianca A. Lepe· 1 shared Carl C. Hayden· 1 shared Eileen M. LaferiD· 1 shared Hattie ChungiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBioengineering

Bryan D. BrysonORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Bacterial surface display enables lysis-independent joint host-pathogen single-cell profiling

Cal Gunnarsson, Jeff C. Hsiao, Jacob B. Hochfelder, Sydney L. Solomon, Bianca A. Lepe, Sharon Zhu, Kelly Xu, Hattie Chung, Bryan D. Bryson

This paper introduces a lysis-independent method for joint host-pathogen single-cell profiling using bacterial surface display, enabling analysis of both host and pathogen features in infected cells.

bioRxiv · Jul 22, 2026 · PreprintBioengineering

Systems-level characterization of EGFR kinase inhibitors reveals heterogeneous effects on Mtb-macrophage interactions

Cal Gunnarsson, Rachel A. McGinn, Jacob B. Hochfelder, Bryan D. Bryson

This study examines the effects of EGFR kinase inhibitors on Mtb-macrophage interactions, finding heterogeneous outcomes and both direct and host-dependent mechanisms of action.

bioRxiv · Oct 17, 2025 · PreprintSystems Biology

Clathrin senses membrane curvature

Wade F. Zeno, Jacob B. Hochfelder, Ajay S. Thatte, Liping Wang, Avinash K. Gadok, Carl C. Hayden, Eileen M. Lafer, Jeanne C. Stachowiak

This study shows clathrin is a strong membrane curvature sensor, with its sensitivity amplified by adaptor proteins, highlighting the role of protein networks in curvature sensing.

Biophysical Journal · Jan 30, 2021Peer-reviewedMolecular Biology