Efficient repair of human homozygous genetic mutation by CRISPR/Cas9 mediated interlocus gene conversion
Fei Yang, Jingtao Pang, Guolong Liu, Yang Yang, Shenguang Qin, Ying Zhang, Yongrong Lai, Dan Liang, Yuxuan Wu
This study demonstrates that CRISPR/Cas9-mediated gene conversion can efficiently repair genetic mutations in hematopoietic stem cells without requiring exogenous DNA templates.
bioRxiv · Sep 5, 2022 · PreprintGenetics