Author

Yongrong Lai

First Affiliated Hospital of GuangXi Medical UniversityORCID 0000-0002-0371-1719Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Dan LiangiD· 2 shared Yuxuan WuiD· 2 shared Bin FuiD· 1 shared Changrui FengiD· 1 shared Da Xie· 1 shared Fei YangiD· 1 shared Feiyan ZhaoiD· 1 shared Gongrui Sun· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioengineering

Dan LiangORCID

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2 papers

Recent·Most cited

BioengineeringNature Biomedical EngineeringPeer-reviewedAug 12, 2025

In vivo genome editing of human hematopoietic stem cells for treatment of blood disorders by mRNA delivery

Saijuan Xu, Dan Liang, Qiudao Wang…·Yuxuan Wu

This paper develops an antibody-free lipid nanoparticle system for in vivo mRNA delivery to human HSCs, enabling efficient base editing of HBG to treat blood disorders like beta-thalassemia and sickle cell disease.

29 citationstop 1%

humanexperimental assay

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GeneticsbioRxivPreprintSep 5, 2022

Efficient repair of human homozygous genetic mutation by CRISPR/Cas9 mediated interlocus gene conversion

Fei Yang, Jingtao Pang, Guolong Liu…·Yuxuan Wu

This study demonstrates that CRISPR/Cas9-mediated gene conversion can efficiently repair genetic mutations in hematopoietic stem cells without requiring exogenous DNA templates.

DOI 10.1101/2022.09.05.506576

humanCRISPR screen

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