Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity
Jason J. Kwon, Julien Dilly, Shengwu Liu, Eejung Kim, Yuemin Bian, Srisathiyanarayanan Dharmaiah, Timothy H. Tran, Kevin S. Kapner, Seav Huong Ly, Xiaoping Yang, Dana Rabara, Timothy J. Waybright, Andrew O. Giacomelli, Andrew Lee Hong, Sean A. Misek, , Andrew J. Aguirre
This study uses deep mutational scanning to analyze KRAS variants, identifying gain- and loss-of-function mechanisms and their impact on oncogenic activity.
bioRxiv · Oct 22, 2024 · PreprintCancer Biology