Author

Andrew G. Stephen

Frederick National Laboratory for Cancer ResearchORCID 0000-0002-8259-621XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Dominic EspositoiD· 2 shared Dwight V. NissleyiD· 2 shared Alexandria L. SohniD· 1 shared Andrew J. AguirreiD· 1 shared Andrew Lee HongiD· 1 shared Andrew O. GiacomelliiD· 1 shared Arvind RaviiD· 1 shared Belinda WangiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Dominic EspositoORCID

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2 papers

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedSep 15, 2025

An In Vitro BRAF Activation Assay Elucidates Molecular Mechanisms Driving the Disassembly of the Autoinhibited BRAF State

Daniel A. Ritt, David Durrant, Matthew R. Drew…·Deborah K. Morrison

This study develops an in vitro BRAF activation assay to elucidate molecular mechanisms of BRAF disassembly and identifies RAS binding as critical for activation.

9 citations

experimental assay

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Cancer BiologybioRxivPreprintOct 22, 2024

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

Jason J. Kwon, Julien Dilly, Shengwu Liu…·Andrew J. Aguirre

This study uses deep mutational scanning to analyze KRAS variants, identifying gain- and loss-of-function mechanisms and their impact on oncogenic activity.

13 citations

humanproteomics

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