Author

Yuemin Bian

Broad InstituteORCID 0000-0002-5845-772XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Andrew G. StepheniD· 1 shared Andrew J. AguirreiD· 1 shared Andrew Lee HongiD· 1 shared Andrew O. GiacomelliiD· 1 shared Arvind RaviiD· 1 shared Barbara I. LudekeiD· 1 shared Belinda WangiD· 1 shared Christopher T. LemkeiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

Andrew G. StephenORCID

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2 papers

Recent·Most cited

Structural and functional analysis of the Nipah virus polymerase complex

Side Hu, Heesu Kim, Pan Yang, Zishuo Yu, Barbara I. Ludeke, Shawna Mobilia, Junhua Pan, Margaret M. Stratton, Yuemin Bian, Rachel Fearns, Jonathan Abraham

This study determines the cryo-EM structure of the Nipah virus polymerase complex and identifies key domains critical for replication and transcription.

Cell · Jan 20, 2025Peer-reviewedMicrobiology

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

Jason J. Kwon, Julien Dilly, Shengwu Liu, Eejung Kim, Yuemin Bian, Srisathiyanarayanan Dharmaiah, Timothy H. Tran, Kevin S. Kapner, Seav Huong Ly, Xiaoping Yang, Dana Rabara, Timothy J. Waybright, Andrew O. Giacomelli, Andrew Lee Hong, Sean A. Misek, , Andrew J. Aguirre

This study uses deep mutational scanning to analyze KRAS variants, identifying gain- and loss-of-function mechanisms and their impact on oncogenic activity.

bioRxiv · Oct 22, 2024 · PreprintCancer Biology