Author

Seav Huong Ly

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:variant effect prediction· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew J. AguirreiD· 2 shared Andrew O. GiacomelliiD· 2 shared William C. HahniD· 2 shared Alice H. BergeriD· 1 shared Andrew G. StepheniD· 1 shared Andrew Lee HongiD· 1 shared Arvind RaviiD· 1 shared Aviv RegeviD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Andrew J. AguirreORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 22, 2024

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

Jason J. Kwon, Julien Dilly, Shengwu Liu…·Andrew J. Aguirre

This study uses deep mutational scanning to analyze KRAS variants, identifying gain- and loss-of-function mechanisms and their impact on oncogenic activity.

13 citations

humanproteomics

𝕏 PostBluesky

GenomicsbioRxivPreprintNov 16, 2020

Massively parallel phenotyping of variant impact in cancer with Perturb-seq reveals a shift in the spectrum of cell states induced by somatic mutations

Oana Ursu, James T. Neal, Emily K. Shea…·Jesse S. Boehm

The paper uses Perturb-seq to assess the phenotypic impact of somatic variants in cancer, revealing a continuum of gain-of-function KRAS variants.

11 citations

humanscRNA-seq

𝕏 PostBluesky