SMAD4 loss drives cancer chromosomal instability through transcription-replication conflict-induced replication stress
Atmika Paul, Gargee Joshi, Philipp Jungk, Simranjeet Kaur, Shengyu Yao, Ioannis Tsirkas, Nicolas Böhly, Maren Sitte, Gabriela Salinas, Stephan Hamperl, Maik Kschischo, Holger Bastians
This study shows SMAD4 loss causes cancer chromosomal instability by inducing replication stress through transcription-replication conflicts via BMP signaling.
bioRxiv · Dec 19, 2025 · PreprintCancer Biology