Maik Kschischo

This study shows SMAD4 loss causes cancer chromosomal instability by inducing replication stress through transcription-replication conflicts via BMP signaling.

This paper develops a gene expression signature to measure replication stress independently of proliferation, revealing a link between RS and NHEJ repair pathway activity.

This study analyzes chromosomal instability in 33 cancer types, finding distinct associations between whole chromosome instability (W-CIN) and whole genome doubling, and structural chromosomal instability (S-CIN) and homologous recombination deficiency, with implications for drug resistance and prognosis.

MFmap predicts cancer subtypes and similarity between cell lines and tumours using a semi-supervised generative model with high accuracy.

The paper investigates the effects of monosomy in human cells, finding that it impairs proliferation and genomic stability, with partial gene dosage compensation and ribosome biogenesis stress contributing to p53 pathway activation.