Inter-organ communication shapes human metabolic tissue states and resolves anti-diabetic drug response modes in a six-tissue microphysiological system
Marissa I. McGilvrey, Shereen Chew, Mohd Farhan Siddiqui, Ronald Bronson, Merve Uslu, Shicheng Ye, Oscar Ospina, Andrea Mcpherson, Katrina Diel, Matjaz Dogsa, Luther Raechal, Martin Trapečar
This study develops a six-tissue microphysiological system to investigate how inter-organ communication and nutrient conditions influence metabolic tissue states and drug responses to anti-diabetic therapies.
bioRxiv · May 27, 2026 · PreprintBioengineering