Author

Mohd Farhan Siddiqui

Johns Hopkins UniversityORCID 0000-0002-9459-9864Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Assay:CITE-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Martin TrapečariD· 3 shared Merve UsluiD· 3 shared Douglas K. BrubakeriD· 2 shared Luther Raechal· 2 shared Matjaz Dogsa· 2 shared Ran RaniD· 2 shared Andrea Mcpherson· 1 shared Carole Y. PerrotiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBioengineering

Martin TrapečarORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Inter-organ communication shapes human metabolic tissue states and resolves anti-diabetic drug response modes in a six-tissue microphysiological system

Marissa I. McGilvrey, Shereen Chew, Mohd Farhan Siddiqui, Ronald Bronson, Merve Uslu, Shicheng Ye, Oscar Ospina, Andrea Mcpherson, Katrina Diel, Matjaz Dogsa, Luther Raechal, Martin Trapečar

This study develops a six-tissue microphysiological system to investigate how inter-organ communication and nutrient conditions influence metabolic tissue states and drug responses to anti-diabetic therapies.

bioRxiv · May 27, 2026 · PreprintBioengineering

Personalized Gut-Liver Microphysiological System Maps Donor-Specific Tissue Resident Immunity and Reveals a Conserved Metabolic Crosstalk

Merve Uslu, Ran Ran, Mohd Farhan Siddiqui, Jing Liang, Luther Raechal, Matjaz Dogsa, Carole Y. Perrot, Linda A. Lieberman, Douglas K. Brubaker, Martin Trapečar

The paper builds a personalized gut-liver microphysiological system to study donor-specific immune profiles and reveals a conserved metabolic crosstalk between gut and liver.

bioRxiv · May 5, 2025 · PreprintBioengineering

Single-Cell Analysis Reveals Tissue-Specific T Cell Adaptation and Clonal Distribution Across the Human Gut-Liver-Blood Axis

Ran Ran, Merve Uslu, Mohd Farhan Siddiqui, Douglas K. Brubaker, Martin Trapečar

The paper tracks T cell clones across gut, liver, and blood using single-cell RNA and TCR sequencing, revealing tissue-specific adaptations and limited overlap between colonic IELs and lamina propria T cells.

bioRxiv · Mar 11, 2025 · PreprintImmunology