Author

Martin Trapečar

Johns Hopkins UniversityORCID 0000-0002-0860-8948Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:scRNA-seq· 3 Research Focus:cell-cell communication· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:CITE-seq· 1

Frequent Co-Authors

Douglas K. BrubakeriD· 3 shared Merve UsluiD· 3 shared Mohd Farhan SiddiquiiD· 3 shared Ran RaniD· 3 shared Luther Raechal· 2 shared Matjaz Dogsa· 2 shared Andrea Mcpherson· 1 shared Carole Y. PerrotiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

Douglas K. BrubakerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Inter-organ communication shapes human metabolic tissue states and resolves anti-diabetic drug response modes in a six-tissue microphysiological system

Marissa I. McGilvrey, Shereen Chew, Mohd Farhan Siddiqui, Ronald Bronson, Merve Uslu, Shicheng Ye, Oscar Ospina, Andrea Mcpherson, Katrina Diel, Matjaz Dogsa, Luther Raechal, Martin Trapečar

This study develops a six-tissue microphysiological system to investigate how inter-organ communication and nutrient conditions influence metabolic tissue states and drug responses to anti-diabetic therapies.

bioRxiv · May 27, 2026 · PreprintBioengineering

Personalized Gut-Liver Microphysiological System Maps Donor-Specific Tissue Resident Immunity and Reveals a Conserved Metabolic Crosstalk

Merve Uslu, Ran Ran, Mohd Farhan Siddiqui, Jing Liang, Luther Raechal, Matjaz Dogsa, Carole Y. Perrot, Linda A. Lieberman, Douglas K. Brubaker, Martin Trapečar

The paper builds a personalized gut-liver microphysiological system to study donor-specific immune profiles and reveals a conserved metabolic crosstalk between gut and liver.

bioRxiv · May 5, 2025 · PreprintBioengineering

Single-Cell Analysis Reveals Tissue-Specific T Cell Adaptation and Clonal Distribution Across the Human Gut-Liver-Blood Axis

Ran Ran, Merve Uslu, Mohd Farhan Siddiqui, Douglas K. Brubaker, Martin Trapečar

The paper tracks T cell clones across gut, liver, and blood using single-cell RNA and TCR sequencing, revealing tissue-specific adaptations and limited overlap between colonic IELs and lamina propria T cells.

bioRxiv · Mar 11, 2025 · PreprintImmunology

Systematic Analysis of Human Colorectal Cancer scRNA-seq Revealed Limited Pro-tumoral IL-17 Production Potential in Gamma Delta T Cells

Ran Ran, Martin Trapečar, Douglas K. Brubaker

This study analyzes scRNA-seq data from human colorectal cancer to show that gamma delta T cells do not produce pro-tumoral IL-17, functioning mainly as cytotoxic effector cells.

Neoplasia · Oct 23, 2024Peer-reviewedImmunology