Author

Sherif Negm

University of Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Bioinformatics· 1 Evolutionary Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:whole-genome sequencing· 4 Organism:Drosophila· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:phylogenetics / evolution· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Amanda M. LarracuenteiD· 4 shared John S. SprouliD· 4 shared Xiaolu WeiiD· 2 shared Anya GreenbergiD· 1 shared Beatriz M. Navarro-DomíngueziD· 1 shared Carl VelleriD· 1 shared Cécile CourretiD· 1 shared Danielle E. KhostiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersGenomics

Amanda M. LarracuenteORCID

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Author profile →

5 papers

Recent·Most cited

Satellite DNA dynamics across phylogenetic scales in ground beetles and other insects

Zachary S Warner, Sherif Negm, Patrick Wynn, Tuan Minh Pham, Lorraine Zaki, Gilbert Giri, Paul B. Frandsen, Amanda M. Larracuente, John S. Sproul

The paper examines satellite DNA dynamics across multiple insect orders and ground beetle species, revealing significant variation in satDNA abundance and turnover across evolutionary scales.

bioRxiv · Jun 9, 2026 · PreprintEvolutionary Biology

The effect of long-range linkage disequilibrium on allele-frequency dynamics under stabilizing selection

Sherif Negm, Carl Veller

The paper shows that linkage disequilibria from stabilizing selection slow allele-frequency dynamics and provides more accurate predictions than previous formulas.

PLoS Genetics · Mar 9, 2026Peer-reviewedGenetics

Centromere-associated retroelement evolution in Drosophila melanogaster reveals an underlying conflict

Lucas W. Hemmer, Sherif Negm, Xuewen Geng, Cécile Courret, Beatriz M. Navarro-Domínguez, Iain Speece, Xiaolu Wei, Eddyson Altidor, James Chaffer, John S. Sproul, Amanda M. Larracuente

The paper studies the evolution of G2/Jockey-3, a retroelement associated with centromeres in Drosophila melanogaster, finding it is likely a selfish element that targets centromeres to evade host defenses.

bioRxiv · Nov 25, 2022 · PreprintGenomics

RepeatProfiler: a pipeline for visualization and comparative analysis of repetitive DNA profiles

Sherif Negm, Anya Greenberg, Amanda M. Larracuente, John S. Sproul

RepeatProfiler generates and compares repetitive DNA profiles from low-coverage data to study evolutionary history in diverse species.

Molecular Ecology Resources · Dec 4, 2020Peer-reviewedBioinformatics

Dynamic evolution of euchromatic satellites on the X chromosome in Drosophila melanogaster and the simulans clade

John S. Sproul, Danielle E. Khost, Danna G. Eickbush, Sherif Negm, Xiaolu Wei, Isaac Wong, Amanda M. Larracuente

The paper studies the evolutionary dynamics of two satellite DNAs in Drosophila species, showing their dynamic changes in location, abundance, and composition across species.

Molecular Biology and Evolution · Mar 18, 2020Peer-reviewedGenomics