Turning microglia neuroprotective: Towards connexin43-specific therapy of Alzheimer's disease
Yixun Su, Hui Li, Wenjie Zhang, Shi Tao, Qi Wang, Mi Zhou, Yong Tang, Hui Chen, Alexei Verkhratsky, Zhengbao Zha, Jianqin Niu, Chenju Yi
This study identifies microglial connexin43 hemichannels as a therapeutic target for Alzheimer's disease, showing that blocking them reduces pathology and cognitive impairment in mouse models.
bioRxiv · Aug 6, 2024 · PreprintNeuroscience