Live imaging and multimodal profiling reveal transdifferentiation of a cochlear supporting cell subpopulation upon Notch inhibition
Lama Khalaily, Shahar Kasirer, Katherine Domb, Mi Zhou, Buwei Shao, Shahar Taiber, Ran Elkon, Litao Tao, David Sprinzak, Karen B. Avraham
The paper identifies a rare subpopulation of cochlear supporting cells that transdifferentiate into hair cells upon Notch inhibition, revealing epigenetic and transcriptional changes associated with this process.
Science Advances · Jun 17, 2026Peer-reviewedDevelopmental Biology