Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation
Tomoki Takei, Yukiko Sasazawa, Daisuke Noshiro, Mitsuhiro Kitagawa, Tetsushi Kataura, Hiroko Hirawake‐Mogi, Emi Kawauchi, Yuya Nakano, Etsu Tashiro, Tsuyoshi Saitoh, Shigeru Nishiyama, Seiichiro Ogawa, Soichiro Kakuta, Saiko Kazuno, Yoshiki Miura, , Nobutaka Hattori
This study shows that ubiquilin-2 droplets catalyze α-synuclein fibril formation in vitro and in cells, and identifies a compound that inhibits this process.
The EMBO Journal · Oct 14, 2025Peer-reviewedBiochemistry