Nobuo N. Noda

Structural and mechanistic basis for membrane recognition and activation of the vacuolar lipase Atg15

This study identifies structural and mechanistic principles of Atg15 activation and membrane recognition using MD simulations and experimental validation.

Thermo-Sensing Mechanisms of Splicing Control by Nuclear Stress Bodies

The paper identifies phosphorylation events and thermosensing mechanisms that regulate CLK1 localization to nuclear stress bodies during thermal stress recovery.

ATG deficiency impairs stationary-phase microlipophagy through acetic acid-induced clustering of Niemann-Pick type C proteins

The paper shows that ATG deficiency impairs stationary-phase microlipophagy in yeast due to acetic acid-induced NPC protein clustering, which can be rescued by reducing extracellular acetic acid.

Reversible One-way Lipid Transfer at ER-Autophagosome Membrane Contact Sites via Atg2

The paper uses a novel fluorescent probe to show reversible phospholipid transfer between ER and autophagosome membranes in vivo.

Mitochondrial fission during mitophagy requires both inner and outer mitofissins

This study identifies Mfi2, a mitochondrial outer membrane microprotein required for mitophagy, showing that both inner and outer mitofissins are needed for mitochondrial fission during mitophagy.

Ubiquilin-2 liquid droplets catalyze α-synuclein fibril formation

This study shows that ubiquilin-2 droplets catalyze α-synuclein fibril formation in vitro and in cells, and identifies a compound that inhibits this process.

Phase separation promotes Atg8 lipidation for autophagy progression

This study shows that phase separation of the Atg1 complex forms the PAS, which facilitates Atg8 lipidation and autophagosome formation in yeast.

Atg1 phosphorylates Atg2 to gate phospholipid flow through a continuous conduit for autophagosome biogenesis

The paper shows Atg1 phosphorylates Atg2 to enable lipid transport for autophagosome formation in yeast.

The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy

The paper identifies the triad interaction between ULK1, ATG13, and FIP200 as essential for ULK complex formation and autophagy initiation.

A role for condensin-mediator interaction in mitotic chromosomal organization

This study identifies a condensin-mediator interaction in fission yeast that is essential for mitotic chromosomal organization and segregation.