Cellular fitness is determined by ribosomal protein S12-mediated release of a truncated Xrp1
Bungo Kakemura, Hiroshi Kanda, Ryo Matsumoto, Shiori Ueda, Satoshi Yasuhara, Rina Nagata, Kiichiro Taniguchi, Shu Kondo, Keita Miyoshi, Tomoe Kobayashi, Kazuhiro Takeuchi, Kuniaki Saito, Makoto Matsuyama, Yasuhiro Murakawa, Tatsushi Igaki
The paper identifies a post-transcriptional mechanism where ribosomal protein S12 regulates Xrp1 expression through alternative splicing, leading to cell death in unfit cells.
Cell Reports · Mar 26, 2026Peer-reviewedCell Biology