Kuniaki Saito

The paper investigates the location dependence of protein intrinsic disorder in Drosophila melanogaster, finding that disorder is more common at terminals and linked to specific functions like protein-binding.

This study shows m1A58 regulates tRNA maturation and XRN2-mediated decay in human cells, maintaining tRNA homeostasis.

The paper identifies a post-transcriptional mechanism where ribosomal protein S12 regulates Xrp1 expression through alternative splicing, leading to cell death in unfit cells.

The paper shows that XRN2-dependent decay of mG-hypomodified tRNAs occurs under physiological conditions and is conserved across species.

The paper shows that repressive SAM biosynthesis in Drosophila germline inhibits HeT-A retrotransposon transcription via 6mA methylation.

The paper identifies Osiris genes as key regulators of cuticle nanostructures in Drosophila, showing their expression in cuticle-secreting cells and their role in shaping specific nano-patterns.

This study shows that Mettl1-dependent m7G tRNA modification is essential for spermatogenesis and fertility in Drosophila, as its loss leads to sterility and tRNA instability.

The paper shows Mod(mdg4)-N variants repress HeT-A retrotransposons by blocking subtelomeric enhancers in Drosophila ovarian cells, leading to female sterility.

This study investigates piRNA size variations and PIWI protein dynamics during hamster oocyte maturation, revealing stage-specific piRNA binding and transcriptional regulation in ovarian piRNA clusters.

The paper updates TRiP's RNAi and CRISPR fly stocks, presenting over 5,000 CRISPR-OE and -KO stocks for gene activation and knockout studies in Drosophila.

The paper identifies Nxf2 as a key component in the Piwi-piRNA pathway, showing it forms complexes that stabilize Piwi and Panx and initiate co-transcriptional silencing of target transcripts.