Tatsushi Igaki

This study identifies three distinct mechanisms by which Xrp1 is induced in response to different stresses in Drosophila, highlighting its role in the Integrated Stress Response.

The paper shows that Iro-C/IRX creates anti-cancerized fields by repressing IL-6 in Drosophila, preventing malignant tumorigenesis.

The paper identifies a post-transcriptional mechanism where ribosomal protein S12 regulates Xrp1 expression through alternative splicing, leading to cell death in unfit cells.

The paper shows that an ancestral LTR retrotransposon insertion in the common ancestor of Euarchontoglires drives lineage-specific genomic imprinting of ZDBF2 through post-fertilization transcription initiation.

This paper introduces flow zoometry, a high-throughput screening method for Drosophila, enabling rapid, automated, and high-resolution analysis of whole animals.

The paper shows JNK signaling increases exocytosis in dying cells, promoting Wg secretion and cell-turnover in Drosophila wing development.